WebThus, there is a continuing interest in understanding the cellular functions of the lysosome and an emerging approach to this is the identification of its constituent proteins by proteomic analyses. To date, the mammalian lysosome has been shown to contain approximately 60 soluble luminal proteins and approximately 25 transmembrane proteins. WebApr 12, 2024 · We explored the effect of thrombin on human aortic smooth muscle cells (HASMCs) and further analyzed its role in the pathogenesis of atherosclerosis (AS). Thrombin-induced differentially expressed genes (DEGs) in HASMCs were identified by analyzing expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, PPI …
Integrative analysis of HASMCs gene expression profile revealed …
WebJul 11, 2011 · Experiments with chimeric proteins made up of sequences from RILP and RLP1 (RILPL1; 614092) revealed a 62-amino acid domain in RILP that was necessary to regulate lysosome morphology. The ability to regulate lysosomes correlated with the ability of the chimeric protein to interact with GTP-bound RAB7 or both GTP-bound RAB7 and … WebProvided are a constitutive promoter CAR-Mut, an expression construct comprising the promoter and a GAA coding nucleotide sequence functionally linked thereto, a recombinant vector, and a host cell. Also provided are a composition and method for delivering a GAA coding polynucleotide to a mammalian cell or individual using the recombinant vector, … female winter dresses
Original article
WebThe LAMP2 gene provides instructions for making a protein called lysosomal associated membrane protein-2 (LAMP-2), which, as its name suggests, is found in the membrane of cellular structures called lysosomes. Lysosomes are compartments in the cell that digest and recycle materials. The role the LAMP-2 protein plays in the lysosome is unclear. Some … WebApr 15, 2024 · The GO analysis is a commonly used approach providing functional studies of large-scale genomic or transcriptomic data. 24 Kyoto Encyclopedia of Genes and Genomes (KEGG) database collects the pathway-related information about how molecules are networked. 25 In the present study, the GO functional analysis comprising three ontology … WebAll lysosomal genes and 12 breast cancer-related genes aligned to identify the most similar genes to breast cancer-related genes. Different centralities were applied to score each human... female winter soldier fanfic