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The human lysosome gene database

WebThus, there is a continuing interest in understanding the cellular functions of the lysosome and an emerging approach to this is the identification of its constituent proteins by proteomic analyses. To date, the mammalian lysosome has been shown to contain approximately 60 soluble luminal proteins and approximately 25 transmembrane proteins. WebApr 12, 2024 · We explored the effect of thrombin on human aortic smooth muscle cells (HASMCs) and further analyzed its role in the pathogenesis of atherosclerosis (AS). Thrombin-induced differentially expressed genes (DEGs) in HASMCs were identified by analyzing expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, PPI …

Integrative analysis of HASMCs gene expression profile revealed …

WebJul 11, 2011 · Experiments with chimeric proteins made up of sequences from RILP and RLP1 (RILPL1; 614092) revealed a 62-amino acid domain in RILP that was necessary to regulate lysosome morphology. The ability to regulate lysosomes correlated with the ability of the chimeric protein to interact with GTP-bound RAB7 or both GTP-bound RAB7 and … WebProvided are a constitutive promoter CAR-Mut, an expression construct comprising the promoter and a GAA coding nucleotide sequence functionally linked thereto, a recombinant vector, and a host cell. Also provided are a composition and method for delivering a GAA coding polynucleotide to a mammalian cell or individual using the recombinant vector, … female winter dresses https://healinghisway.net

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WebThe LAMP2 gene provides instructions for making a protein called lysosomal associated membrane protein-2 (LAMP-2), which, as its name suggests, is found in the membrane of cellular structures called lysosomes. Lysosomes are compartments in the cell that digest and recycle materials. The role the LAMP-2 protein plays in the lysosome is unclear. Some … WebApr 15, 2024 · The GO analysis is a commonly used approach providing functional studies of large-scale genomic or transcriptomic data. 24 Kyoto Encyclopedia of Genes and Genomes (KEGG) database collects the pathway-related information about how molecules are networked. 25 In the present study, the GO functional analysis comprising three ontology … WebAll lysosomal genes and 12 breast cancer-related genes aligned to identify the most similar genes to breast cancer-related genes. Different centralities were applied to score each human... female winter soldier fanfic

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The human lysosome gene database

Human Gene Set: LYSOSOME - gsea-msigdb.org

WebJan 19, 2016 · The expanding role of the lysosome in human diseases. Mutations in genes encoding proteins involved in lysosomal function cause lysosomal storage diseases (LSDs), a group of about 50 inherited disorders characterized by the progressive accumulation of undegraded substrates inside the lysosome. Patients with LSDs present with a … WebDec 10, 2024 · Lysosomes have recently been recognized as ‘acidic Ca 2+ stores’, and lumenal Ca 2+ is central to diverse functions 3. Lysosome function is particularly important in neurons given the...

The human lysosome gene database

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WebMar 25, 2024 · In the present study, elevated glucose resulted in a marked reduction in expression of 8 of the 26 genes classified as hydrolases, 5 of the 9 genes classified as … WebLysosome-associated membrane protein 2 ( LAMP2 ), also known as CD107b ( C luster of D ifferentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins . The protein encoded by this gene is a member of a family of membrane glycoproteins.

WebJun 25, 2009 · We found that most lysosomal genes exhibit coordinated transcriptional behavior and are regulated by the transcription factor EB (TFEB). Under aberrant lysosomal storage conditions, TFEB translocated from the cytoplasm to the nucleus, resulting in the activation of its target genes. WebJun 7, 2024 · Lysosomes are degradation centers and signaling hubs in cells and play important roles in cellular homeostasis, development, and aging. Changes in lysosome function are essential to support cellular adaptation to multiple signals and stimuli. Therefore, lysosome biogenesis and activity are regulated … Lysosome biogenesis: …

WebJun 25, 2009 · Fig. 1 A regulatory gene network controlling the expression of lysosomal genes. (A) Genomic distribution of CLEAR elements (red dots) at human gene … WebNov 2, 2024 · We identified 604 genes and created main categories: MTOR and upstream pathways, autophagy core, autophagy transcription factors, mitophagy, docking and fusion, lysosome and lysosome-related...

Web8 rows · Apr 12, 2013 · The Human Lysosome Gene Database (hLGDB) is the first resource that provides a comprehensive and ...

WebNov 2, 2024 · We identified 604 genes and created main categories: MTOR and upstream pathways, autophagy core, autophagy transcription factors, mitophagy, docking and … deflate tires for snowWebApr 15, 2024 · This enclosure contains natural dirt flooring, is built into a human-occupied environment, and contains a mesh shade sail as covering. ... 16S rRNA gene database (NCBI BioProjects 33,175 and 33,317). Both taxonomic classifiers were built using q2-rescript and trained using the fit-classifier-naïve-bayes tool prior to use. Classification was ... deflate wobble cushionWebPurchase Recombinant Chicken Lysozyme C(LYZ),Biotinylated. It is produced in E.coli. High purity. Good price. deflate the tireWebJun 22, 2024 · Using this method, we show white/grey hairs that naturally regain pigmentation across sex, ethnicities, ages, and body regions, thereby quantitatively defining the reversibility of greying in humans. Molecularly, grey hairs upregulate proteins related to energy metabolism, mitochondria, and antioxidant defenses. female winter hatsWebNational Center for Biotechnology Information deflate transform text effect in warp in wordWebMar 25, 2024 · For any given gene list, the Database for Annotation, Visualization ... there were only 12 genes common between the training and validation lysosome gene list but both of the training gene-sets networks found ... S2 Fig. Expression of mTOR and its associated genes in cultures of glucose treated human proximal tubular cells. Human … female winter jacketWebGene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. LOC118461668 lysosome-associated membrane glycoprotein 2-like [] Gene ID: 118461668, ... Other designations. lysosome-associated membrane glycoprotein 2-like ... deflate trach cuff