WebbHowever, the optimization of ribosome utilization may decrease the overall protein production which can be compensated by increasing the copy number of heterologous transcripts. ... Therefore, a trade-off is possible between ribosome utilization and the efficiency of other co-translational processes which require further investigations. Webb19 maj 2024 · Theoretically a gradual decrease of translated protein along a polycistronic vector is expected due to naturally occurring ribosome drop-off at a constant rate that is positively correlated with ...
Novel mRNA-specific effects of ribosome drop-off on translation …
Webb28 nov. 2024 · Ribo-uORF is a comprehensive database that provides valuable resources and analysis tools for the identification and characterization of uORFs based on ribosome profiling data and several related resources. Issue Section: Database Issue INTRODUCTION Gene expression is regulated at both transcriptional and posttranscriptional levels. Webb17 maj 2024 · Thus, in the latter case, two adjacent ribosomes move forward simultaneously. Protein elongation is in competition with ribosome drop-off that occurs … cordjacke damen only
Novel mRNA-specific effects of ribosome drop-off on translation …
Webbleaving the mRNA (ribosome ‘drop off’), often fol-lowed by decay of the mRNA and the partly com-pleted protein product. Examples of these distinct outcomes are described below, using examples from viral, prokaryotic and eukaryotic systems. In some cases the different mechanistic consequences of paus-ing are emergency responses to a ... Webb7 apr. 2016 · Ribosome drop-off is not limited to stress conditions; it occurs even when the cell is in a non stressing environment ( 9, 10, 12 ,16–18). In these conditions, the … Webb8 okt. 2024 · Ribosome profiling experiments have shown that these MREs induce a measurable degree of ribosome stalling, but without evident ribosome queuing, thus suggesting that CDS RISC may have both... cordis new jersey