Lysine succinylation-resistant
Web7 iun. 2024 · 蛋白质琥珀酰化修饰 (succinylation) ，作为赖氨酸酰化修饰家族的重要一员，于2011年由芝加哥大学赵英明教授团队在Nature Chemical Biology 发文被首次报道，并被评为该杂志创刊10年39篇精品论文之一 [1]。随后，关于琥珀酰化的调控酶系统（转移酶writer和去修饰酶eraser）和生物学功能也有了越来越多的报道。 WebThe mutagenesis studies confirm that succinylation regulates the enzymatic activities of species-specific proteins PprI and DdrB, which belong to the radiation-desiccation …
Lysine succinylation-resistant
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Web29 aug. 2013 · Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about … Web5 sept. 2024 · Here we report identification of 2580 lysine succinylation sites in 670 proteins, as well as 2806 lysine acetylation sites in 782 proteins in E. coli, representing …
In this study, the dataset of experimentally verified lysine succinylation sites was mainly extracted from PLMD30, which has accumulated 284,780 lysine modification sites from 53,501 proteins among 20 different types of PTMs. When considering only experimentally confirmed lysine … Vedeți mai multe This study aimed at the sequence-based characterization of protein succinylation site specificity. Not only the position-specific amino acid composition (PspAAC) but also the composition of k-spaced amino acid … Vedeți mai multe This study involved a binary classification of lysine residues into succinylated and non-succinylated sites. Due to the emergence of … Vedeți mai multe The composition of k-spaced amino acid pairs (CKSAAP) has been extensively applied in analyses of protein functions28,33,41,44,45,46,47,48,49. This study … Vedeți mai multe To investigate into the substrate-site specificity of succinylated sites, the maximal dependence decomposition (MDD)40 was … Vedeți mai multe Web12 nov. 2014 · Abstract. Protein lysine succinylation, an emerging protein post-translational modification widespread among eukaryotic and prokaryotic cells, represents an important regulator of cellular processes. However, the extent and function of lysine succinylation in Mycobacterium tuberculosis, especially extensively drug-resistant …
Web2 aug. 2013 · Abstract. The posttranslational modification of proteins and their regulation by metabolites represent conserved mechanisms in biology. At the confluence of these two processes, we report that the primary glycolytic intermediate 1,3-bisphosphoglycerate (1,3-BPG) reacts with select lysine residues in proteins to form 3-phosphoglyceryl-lysine (pgK). Web14 apr. 2024 · Yang et al. described a novel role for HAT1 in HepG2 cell lines, in which HAT1 functions as the lysine-succinyl transferase of histone and nonhistone proteins. In HAT1-depleted cells, the succinylation level of 324 sites in 204 proteins is inhibited, and these proteins are widely localized and participate in multiple cellular pathways.
WebTogether, these results provide insight into the role of lysine succinylation in the extreme resistance of D. [10] Lysine succinylation is a form of posttranslational modification of the proteins that play an essential functional role in every aspect of cell metabolism in both prokaryotes and eukaryotes. [11]
Web19 mar. 2024 · Lysine succinylation and sirtuin 5 (SIRT5) connect nutrient availability to metabolic flux. Glutaminase (GLS) initiates the conversion of glutamine to α-ketoglutarate (α-KG) for tricarboxylic acid (TCA) cycle anaplerosis. ... and SIRT5 supports tumorigenesis and/or drug resistance in diverse cancer types. 3,9 In contrast SIRT3 and SIRT4 are ... bmx what does it stand forWeb8 aug. 2024 · acylations but plays the most important role in desuccinylation [11, 17]. Various roles of lysine succinylation (Ksu) in individual proteins have been reported, particularly in relation to cancer progression and metastasis [18-20]. For example, S100A10 was found to be succinylated at lysine residue 47 in gastric cancer. bmx wethepeople reasonWeb15 mar. 2024 · Histone acetylation in epigenetics. Epigenetics is currently one of the fastest-growing areas in biological research. Epigenetics plays an important role in many cellular processes, including regulation of gene expression and transcription, cell growth and differentiation, and chromosome remodeling and inactivation (8, 9).Epigenetics refers to … bmx whiteWeb28 iul. 2016 · Whey-protein-free milk was the most resistant to plasmin, followed by skim milk and lactose-free milk, suggesting that lactosylation plays a more major role than whey protein association with the casein micelles in making protein resistant to plasmin-induced hydrolysis. ... As plasmin hydrolyses proteins on the carboxyl site of lysine and ... bmx wheelchairWeb29 mai 2024 · Lysine succinylation (Ksucc) is a protein posttranslational modification conserved in eukaryotes and prokaryotes that was discovered in 2011 . Compared with acetylation and methylation, Ksucc can cause more changes in protein properties because a succinylated lysine group has two negative charges, which are higher than the charge … clickmeeting regulaminWeb22 iun. 2015 · Lysine residues can be post-translationally modified by various acyl modifications in bacteria and eukarya. Here, we showed that two major acyl modifications, acetylation and succinylation, were changed in response to the carbon source in the Gram-positive model bacterium Bacillus subtilis. Acetylation was more common when the cells … bmx why notWeb14 mai 2024 · In addition, reconstituted expression of RNAi-resistant (r) wild-type (WT) FLAG-rGLS and FLAG-rGLS K311R in endogenous GLS-depleted AsPC-1 and SW1990 cells (Figure S2G) showed that the rGLS K311R mutant is succinylated to a considerably lesser extent than its WT counterpart, as detected by an anti-pan-lysine succinylation … bmx white bike