Webb1 feb. 2002 · YC-1 increased cellular cyclic GMP levels through the activation of sGC and the inhibition of cyclic GMP-hydrolyzing phosphodiesterase activity. The plateau phase, but not the initial spike, of fMLP-induced [Ca(2+)](i) changes was inhibited by YC-1 (IC(50) about 15 microM). fMLP- but not PMA-induced phospholipase D activation was … Webb5 maj 2024 · Here, we showed that a HIF-1α inhibitor, YC-1, potentiated the antitumor efficacy of gefitinib by promoting EGFR degradation in a panel of human NSCLC cells …
IJMS Free Full-Text YC-1 Prevents Tumor-Associated Tissue …
Webb16 nov. 2011 · YC-1 (Cayman Chemical Company, Ann Arbor, MI), dissolved in a solution of 1% dimethyl sulfoxide (DMSO), was administered at 2 mg/kg body weight through femoral vein at 24 hr and 30 min prior to the onset of ischemia. Rats in control groups received equivolume injections of the DMSO solution. Webb12 aug. 2024 · In vivo, pharmacological USP7 inhibition attenuates microglia activation and resultant neuron injury, thereby notably improving behavioral deficits in dementia … shopttkits.com
YC-1 potentiates the antitumor activity of gefitinib by inhibiting …
WebbInhibition är inom juridiken ett beslut av en högre instans att inställa verkställighet av en dom eller ett beslut. [1]Inhibitionen innebär inte att domen eller beslutet upphävs, enbart att verkställigheten har skjutits upp. Ofta fattas beslut om inhibition om ett beslut har överklagats till högre rätt och det ännu är oklart om det kommer att verkställas efter … Webb26 dec. 2013 · LNCaP cells were treated with YC-27 800CW in combination with either unlabeled YC-27 (Figure 2 (c)) or with 2-PMPA, a potent competitive inhibitor of PSMA … Webb15 dec. 2024 · CTLA-4 is a transmembrane protein encoded by the CTLA-4 gene, expressing in activated CD4 + (auxiliary) and CD8 + (cytotoxic) T cells. By binding with its ligand B7 molecules, CTLA-4 produces inhibitory signals and inhibits the activation of T cells [ 5, 6, 7] to protect the tumor cell from attack. shop ttne