E2F4 and E2F5 represent the E2F class of repressors governed by pocket proteins. Both members are nuclear during early stages of the cell cycle and are thought to be necessary to repress cell cycle gene activity, but become exported from the nucleus as the cell cycle continues and cell cycle genes should be expressed … See more E2F6 was the first E2F family member identified which did not have a C-terminal activation domain and was a strong repressor of E2F activity [67]. When over-expressed, E2F6 has been demonstrated to inhibit cell cycle … See more E2F7 and E2F8 represent the last group of E2Fs that have been identified. Like E2F6 they are not regulated by pocket proteins and unlike all other E2Fs, they do not dimerize with DPs. … See more WebJan 13, 2024 · Rationale: The E2F pathway plays a critical role in cardiac growth and development, yet its role in cardiac metabolism remains to be defined. Metabolic …
E2F and p53 make a nice couple: converging pathways in apoptosis
WebApr 18, 2005 · The E2 factor (E2F) family of transcription factors are downstream effectors of the retinoblastoma (RB) protein pathway and are believed to play a pivotal role in cell division control. Since its ... WebThe E2F1 transcription factor is a critical downstream target of the tumor suppressor RB. When activated, E2F1 induces cell proliferation. In addition, E2F1 can induce apoptosis via both p53-dependent and p53-independent pathways. A number of E2F-regulated genes, including ARF, ATM and Chk2, contrib … t-shirts 5xl
Genome-Wide Identification Transcriptional Expression Analysis of E2F ...
WebJan 13, 2024 · In essence, E2F6 serves as a dominant negative of E2F/Rb in the heart. E2F6-Tg mice display an early reduction in connexin-43(CX-43) and reduced conductivity which is a hallmark of DCM and heart ... WebThe deduced 437-amino acid E2F1 protein has a calculated molecular mass of 47 kD and contains a nuclear localization signal. Northern blot analysis detected a 3.1-kb transcript that was highly expressed in heart, brain, and placenta and more weakly expressed in skeletal muscle, kidney, and pancreas. WebThe current understanding of the E2F pathway and its contribution to normal and pathological cardiac development and growth is summarized. Regulation of the cardiac … t shirts 5x