2024 Cisplatin induced cardiotoxicity

Cisplatin induced cardiotoxicity

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WebJan 27, 2016 · Main features and mechanisms of cardiotoxicity from nonanthracycline chemotherapy. The cardiotoxic effects produced by antineoplastic agents can be permanent (type I CTX) or reversible (type II), and can be induced at distinct levels and intensities. A distinguishing feature of type I chemotherapy-induced CTX is the induction of … WebAug 17, 2024 · Cisplatin-induced cardiotoxicity has been reported to mainly include arrhythmia, acute myocardial infarction, supraventricular tachycardia, and atrial fibrillation …

Cisplatin-induced cardiotoxicity Mechanisms and …

WebJan 30, 2024 · Results: Numerous antioxidants (such as thiol compounds, polyphenols, vitamins, etc.) had been reported for their beneficial effects on cisplatin-induced cardiotoxicity. The effects of various antioxidants, including sulfur-containing amino acids, have also been explored for mitigation of cisplatin neurotoxicity. WebSep 1, 2024 · Cisplatin-induced cardiotoxicity severely limits its clinical application as an antitumor drug and increases the risk of cardiovascular disease. Icariin (ICA), the main … taste of his own medicine synonym

The cardioprotective effect of human glucagon-like peptide-1 …

WebDrug-induced cardiotoxicity limits or forbids further use of the implicated drugs. Such drugs that are currently available in the clinic include anti-tumor drugs (doxorubicin, cisplatin, trastuzumab, etc.), antidiabetic drugs (rosiglitazone and pioglitazone), and an antiviral drug (zidovudine). WebNov 26, 2024 · 2. Chemotherapy-Induced Toxicity and Free Radicals. Mitochondria is one of the key contributors to cancer development and progression. Most of the O 2 • − generated under physiological conditions are efficiently converted into H 2 O 2 by superoxide dismutase (SOD). Catalase, glutathione peroxidase (GSH-Px, eight … WebJun 1, 2013 · At present, no data is provided explaining the mechanism of NO in cisplatin-induced cardiotoxicity. It has been found that NO and its metabolites, including … taste of hindustan menu

Asperuloside attenuates cadmium-induced toxicity by inhibiting ...

Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity

WebCardiotoxicity has been well documented as a side effect of cisplatin (CDDP) treatment. The inflammatory response plays a crucial role in the pathological process of CDDP … WebFeb 21, 2024 · Cardiotoxicity of trastuzumab and other HER2-targeted agents; Cisplatin nephrotoxicity; Clinical manifestations, diagnosis, and treatment of anthracycline-induced cardiotoxicity; Drug-induced thrombotic microangiopathy (DITMA) Endocrine therapy … the burgundy group incWebJul 27, 2016 · Take for example the side effects of anticancer treatments: just a few years ago, side effects such as cardiotoxicity and myelotoxicity often forced the interruption of life-saving treatments. ... Callejo and colleagues examined in depth the state of art of cisplatin-induced ototoxicity. In addition to peripheral neurotoxicity, cisplatin ... the burgundy apartments dallas tx

"WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al., 2024 " - Cisplatin induced cardiotoxicity

Cisplatin induced cardiotoxicity

Hesperidin protects against cisplatin-induced …

WebApr 4, 2024 · Hesperidin (HES) is an abundant and economical dietary bioflavonoid, and it has several pharmacological properties such as antioxidant activity and powerful cardiac protection. However, HES protection against cisplatin (CP)-induced cardiotoxicity and its mechanism have not been fully clarified. WebJan 10, 2011 · Cisplatin-induced cardiotoxicity Acetyl-l-carnitine DL-α-lipoic acid Silymarin Mitochondrial DNA Apoptosis 1. Introduction Cisplatin is one of the most remarkable successes in ‘the war on cancer’. Since the accidental discovery four decades ago, cisplatin has been widely used for chemotherapy.

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WebQuercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway Authors Shih-Hao Wang 1 2 , Kun-Ling Tsai 3 4 , Wan-Ching Chou 3 , Hui-Ching Cheng 3 , Yu-Ting Huang 3 , Hsiu-Chung Ou 5 , Yun-Ching Chang 6 Affiliations WebCardiotoxicity has also been linked to cisplatin treatment. The leakages of lactate dehydrogenase (LDH) as well as creatine kinase from the cardiac myocytes result from Cardiotoxicity. 39 This could be secondary processes that results from cisplatin-induced lipid peroxidation or cardiac membranes.

WebJan 10, 2011 · Abstract. Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that limits the clinical use of cisplatin as an anti-tumoral drug. Our study …

WebMar 21, 2024 · However, HES protection against cisplatin (CP)-induced cardiotoxicity and its mechanism have not been fully clarified. The current study was performed to … WebJun 1, 2013 · There is evidence that oxidative stress is an important cause of cardiotoxicity by cancer chemotherapy including cisplatin in humans (Demkow et al., 2011, El-Awady et al., 2011, Hussein et al., 2012). The oxidative stress represents an imbalance between excessive generation and/or impaired removal of reactive oxygen species (ROS).

WebIt may be induced by factors including direct toxicity, ion imbalance, heart infiltration and, in the case of neuroendocrine tumors, the influence of tumor excretions. Keywords: …

WebOct 1, 2010 · The increase in MDA may be due to the formation of oxygen-free radicals during cisplatin-induced cardiotoxicity, which react with membrane lipids, proteins, and nucleic acids and can cause ... taste of himalayas sonomaWebSep 15, 2024 · Cisplatin's side effects primarily include nephrotoxicity, gastrointestinal toxicity, neurotoxicity and ototoxicity. Cardiotoxicity is generally not defined as a side effect of cisplatin. However, over the past decade there has been a surge in the amount of clinical cases reporting a vast array of cardio-toxic events occurring during or shortly ... taste of himalayas lunch buffet priceWebDec 30, 2015 · El-Awady el-SE, Moustafa YM, Abo-Elmatty DM, Radwan A. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. Eur Eur J … taste of history recipesWebApr 15, 2024 · Cisplatin is mostly used in combination with other chemotherapy drugs to overcome drug-resistance and reduce toxicity [reviewed in ( 95 )]. Cisplatin-based chemotherapy has been reported to cause cardiovascular diseases, particularly myocardial infarction and angina, in a range of 7–32% of patients ( 96) [reviewed in ( 97 )]. taste of himalayas near meWebOct 20, 2024 · Study results showed that Cis explored acute cardiotoxicity evidenced by deteriorated cardiac indices, induction of oxidative stress, and inflammation with myocardium histological alterations.... the burgundy condominiumsWebMar 21, 2024 · Cisplatin (CP) kills tumour cells by inducing senescence or triggering innate apoptotic pathways that cause irreparable DNA damage, and it is the most commonly used first-line drug for cancer treatment. 1 However, its clinical use is often limited by dose-related cardiotoxicity, 2 which includes arrhythmias, 3 angina pectoris, 4 and cardiac … taste of history restaurantWebThe current study aimed to investigate the curative role of semaglutide's against cisplatin- induced cardiotoxicity and its relation to mitochondrial functions, dynamics, biogenesis, apoptosis, and redox status pathways. The study included 30 male rats divided into three groups: control, cisplatin-induced cardiotoxicity, and cisplatin-induced ... taste of history cookware